Natural products continue to be a promising source of new drug leads, however, better prioritization techniques are constantly needed. Bioactivity profiling is a technique that facilitates the discovery of bioactive compounds with unique modes of action or targets from natural product extracts. This study aimed to investigate a simplified method of bioactivity profiling to determine the potential limitations with respect to screening concentrations, and matrix effects due to the extract surrounding. The results showed that the screening concentration affected bioactivity profiles and that bioactivity profiles of antimicrobial compounds in an extract matrix were different to those of antimicrobials alone. This study improved the Natural Product Research Group’s bioactivity profiling technique and could be a promising tool for prioritizing collections of natural product extracts.
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