Cost efficient, scalable asymmetric synthesis of bronze birch borer kairomone (5s,7s)-7-Methyl-1,6-dioxaspiro[4.5]decane

Abstract

With the increased use of birch trees, specifically non-native birches in parks, and beautification projects, an increase of infestations by the bronze birch borer (Agrilus anxius) has occurred. While reactive measures are available to try to remediate infested trees, a proactive strategy is not as widely available. (5S,7S)-7-Methyl-1,6-dioxaspiro[4.5]decane (5S,7S-conophthorin) has been identified as a possible kairomone that attracts bronze birch borers to susceptible trees. These susceptible trees include Eurasian varieties and stressed native North American species. While synthesized in the past, a scalable, cost efficient synthesis of this kairomone will likely enable its production industrially, and help allow for mass detection/trapping strategies of the pest to be implemented before infestations occur.