Morehouse, Nicholas J.Graham, Kelsie M.Cox, Samantha L.Johnson, John A.Gray, Christopher A.2024-07-172024-07-172023-10-301480-3291https://unbscholar.lib.unb.ca/handle/1882/38043A new phenalenone derivative, 2,4,6,9-tetrahydroxy-7-methyl-2-prenyl-1H-phenalene 1,3(2H)-dione (1), was isolated from the ethyl acetate extract of a marine derived Penicillium sp. fungus that exhibited a unique antimicrobial activity profile. The planar structure of 1 was determined through a combination of 1D and 2D NMR experiments, and circular dichroism and polarimetry indicated that it was isolated as a racemic mixture of enantiomers. The antimicrobial activity of 1 was assessed against a panel of Gram-positive and Gram-negative bacteria and fungal strains and it was found to selectively inhibit the growth of Staphylococcus aureus and Mycobacterium tuberculosis. Keywords: Phenalenone, Penicillium, Natural product, Antimicrobialenhttp://purl.org/coar/access_right/c_abf2journal articleChemistry