The development and application of a simplified bioactivity profiling strategy to natural product discovery

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dc.contributor.advisorGray, Christopher
dc.contributor.authorVeljanovska, Marija
dc.date.accessioned2023-03-01T16:24:42Z
dc.date.available2023-03-01T16:24:42Z
dc.date.issued2019
dc.date.updated2023-03-01T15:02:07Z
dc.description.abstractNatural products continue to be a promising source of new drug leads, however, better prioritization techniques are constantly needed. Bioactivity profiling is a technique that facilitates the discovery of bioactive compounds with unique modes of action or targets from natural product extracts. This study aimed to investigate a simplified method of bioactivity profiling to determine the potential limitations with respect to screening concentrations, and matrix effects due to the extract surrounding. The results showed that the screening concentration affected bioactivity profiles and that bioactivity profiles of antimicrobial compounds in an extract matrix were different to those of antimicrobials alone. This study improved the Natural Product Research Group’s bioactivity profiling technique and could be a promising tool for prioritizing collections of natural product extracts.
dc.description.copyright©Veljanovska, 2020
dc.description.noteElectronic Only.
dc.formattext/xml
dc.format.extentx, 184 pages
dc.format.mediumelectronic
dc.identifier.urihttps://unbscholar.lib.unb.ca/handle/1882/13773
dc.language.isoen_CA
dc.publisherUniversity of New Brunswick
dc.rightshttp://purl.org/coar/access_right/c_abf2
dc.subject.disciplineBiology
dc.titleThe development and application of a simplified bioactivity profiling strategy to natural product discovery
dc.typemaster thesis
thesis.degree.disciplineBiology
thesis.degree.fullnameMaster of Science in Biological Sciences
thesis.degree.grantorUniversity of New Brunswick
thesis.degree.levelmasters
thesis.degree.nameM.Sc.

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