Confirmation of the absolute stereochemistry of a polymeric natural product from a macroalgal endophyte

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dc.contributor.advisorGray, Christopher
dc.contributor.advisorJohnson, John
dc.contributor.authorMorehouse, Nicholas J.
dc.date.accessioned2023-06-07T18:16:04Z
dc.date.available2023-06-07T18:16:04Z
dc.date.issued2018
dc.description.abstractThe bioactive biopolymer, poly(3,5-dihydroxyhexanoic acid), was previously isolated from an unidentified fungal endophyte of the marine macroalga Scytosiphon lamentaria. Literature reports for this compound failed to provide adequate details about poly(3,5-dihydroxyhexanoic acid) to allow for its complete characterization, thus requiring additional methods to be employed to determine the absolute stereochemistry of poly(3,5-dihydroxyhexanoic acid). Saponification of poly(3,5-dihydroxyhexanoic acid) yielded the lactone, 4-hydroxy-6-methyltetrahydro-2H-pyran-2-one. Nuclear magnetic resonance spectroscopy and polarimetry confirmed that the lactone was the 3R, 5R enantiomer, thus, the biopolymer isolated was confirmed to be poly(3R,5R-dihydroxyhexanoic acid).
dc.description.copyrightThis work is licensed under the Creative Commons Attribution 4.0 International License. To view a copy of this license, visit: http://creativecommons.org/licenses/by/4.0/ or send a letter to Creative Commons, PO Box 1866, Mountain View, CA 94042, USA.
dc.format.extentviii, 28 pages
dc.format.mediumelectronic
dc.identifier.urihttps://unbscholar.lib.unb.ca/handle/1882/31416
dc.language.isoen_CA
dc.publisherUniversity of New Brunswick
dc.rightshttp://purl.org/coar/access_right/c_16ec
dc.subject.disciplineBiology
dc.titleConfirmation of the absolute stereochemistry of a polymeric natural product from a macroalgal endophyte
dc.typesenior report
thesis.degree.disciplineBiology
thesis.degree.fullnameBachelor of Science with Honours in Biology
thesis.degree.grantorUniversity of New Brunswick
thesis.degree.levelundergraduate
thesis.degree.nameB.Sc.

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