Honours Theses

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Investigation of antimicrobial activity of Canadian medicinal plant extracts
(University of New Brunswick, 2018) Dao, Khoi Thien; Gray, Christopher; Johnson, John
Methanolic extracts of seven Canadian medicinal plants were investigated for antimicrobial activity against a Gram-positive bacterium (Staphylococcus aureus), a Gram-negative bacterium (Pseudomonas aeruginosa), and a fungal organism (Candida albicans). Chamerion angustifolium extract was highly bioactive against S. aureus and P. aeruginosa; Crataegus sp. extract was moderately bioactive against S. aureus, but had a low bioactivity against C. albicans. The extract from Betula papyrifera had a low bioactive against both S. aureus and C. albicans. The active constituents of C. angustifolium, Crataegus sp., and B. papyrifera were detected via separation using two-dimensional thin layer chromatography followed by testing against S. aureus using bioautography. This is the first study to report antimicrobial activity of Crataegus sp. native to Canada and first study to find the antimicrobial constituents of C. angustifolium and B. papyrifera.