Characterization of Parelaphostrongylus tenuis excretory glands and identification of alpha-Gal-modified excreted/secreted proteins
| dc.contributor.advisor | Duffy, Michael | |
| dc.contributor.author | Fitzpatrick, Jennifer | |
| dc.date.accessioned | 2023-03-01T16:15:59Z | |
| dc.date.available | 2023-03-01T16:15:59Z | |
| dc.date.issued | 2013 | |
| dc.date.updated | 2023-03-01T15:01:02Z | |
| dc.description.abstract | Adult Parelaphostrongylus tenuis induce a concomitant immunity that protects their deer host against subsequent infections. Although this phenomenon is common among longlived parasitic helminths, molecular mechanisms that mediate concomitant immunity remain unknown. Alpha-Gal is a disaccharide that is stage-restricted, synthesized exclusively by adult stage P. tenuis, suggesting a potential role in mediating concomitant immunity. Current studies identified excretory glands as the principle source of alpha-Gal-modified glycoproteins. Secretory granules are the dominant component of these specialized cells, confirming a primary role for excretory glands in protein secretion and, by extension, parasitism. The alpha-Gal epitope is also synthesized within the deer host and so parasite-derived alpha-Gal is poised to promote immune modulation. A model is proposed for alpha-Gal-mediated modulation of host immune responses to promote concomitant immunity. Two-dimensional immunoblots and mass spectrometry identified galectin and/or Ancylostoma-secreted protein homologues as likely candidates for modification by alpha-Gal. | |
| dc.description.copyright | © Jennifer Fitzpatrick, 2013 | |
| dc.format | text/xml | |
| dc.format.extent | xxiii, 143 pages | |
| dc.format.medium | electronic | |
| dc.identifier.uri | https://unbscholar.lib.unb.ca/handle/1882/13135 | |
| dc.language.iso | en_CA | |
| dc.publisher | University of New Brunswick | |
| dc.rights | http://purl.org/coar/access_right/c_abf2 | |
| dc.subject.discipline | Biology | |
| dc.title | Characterization of Parelaphostrongylus tenuis excretory glands and identification of alpha-Gal-modified excreted/secreted proteins | |
| dc.type | master thesis | |
| thesis.degree.discipline | Biology | |
| thesis.degree.fullname | Master of Science | |
| thesis.degree.grantor | University of New Brunswick | |
| thesis.degree.level | masters | |
| thesis.degree.name | M.Sc. |
Files
Original bundle
1 - 1 of 1