Characterization of Parelaphostrongylus tenuis excretory glands and identification of alpha-Gal-modified excreted/secreted proteins

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dc.contributor.advisorDuffy, Michael
dc.contributor.authorFitzpatrick, Jennifer
dc.date.accessioned2023-03-01T16:15:59Z
dc.date.available2023-03-01T16:15:59Z
dc.date.issued2013
dc.date.updated2023-03-01T15:01:02Z
dc.description.abstractAdult Parelaphostrongylus tenuis induce a concomitant immunity that protects their deer host against subsequent infections. Although this phenomenon is common among longlived parasitic helminths, molecular mechanisms that mediate concomitant immunity remain unknown. Alpha-Gal is a disaccharide that is stage-restricted, synthesized exclusively by adult stage P. tenuis, suggesting a potential role in mediating concomitant immunity. Current studies identified excretory glands as the principle source of alpha-Gal-modified glycoproteins. Secretory granules are the dominant component of these specialized cells, confirming a primary role for excretory glands in protein secretion and, by extension, parasitism. The alpha-Gal epitope is also synthesized within the deer host and so parasite-derived alpha-Gal is poised to promote immune modulation. A model is proposed for alpha-Gal-mediated modulation of host immune responses to promote concomitant immunity. Two-dimensional immunoblots and mass spectrometry identified galectin and/or Ancylostoma-secreted protein homologues as likely candidates for modification by alpha-Gal.
dc.description.copyright© Jennifer Fitzpatrick, 2013
dc.formattext/xml
dc.format.extentxxiii, 143 pages
dc.format.mediumelectronic
dc.identifier.oclc(OCoLC)1322096975en
dc.identifier.otherThesis 9297en
dc.identifier.urihttps://unbscholar.lib.unb.ca/handle/1882/13135
dc.language.isoen_CA
dc.publisherUniversity of New Brunswick
dc.rightshttp://purl.org/coar/access_right/c_abf2
dc.subject.disciplineBiology
dc.subject.lcshParelaphostrongylus tenuis.en
dc.subject.lcshImmunity.en
dc.subject.lcshDeer.en
dc.subject.lcshGlycoproteins.en
dc.titleCharacterization of Parelaphostrongylus tenuis excretory glands and identification of alpha-Gal-modified excreted/secreted proteins
dc.typemaster thesis
thesis.degree.disciplineBiology
thesis.degree.fullnameMaster of Science
thesis.degree.grantorUniversity of New Brunswick
thesis.degree.levelmasters
thesis.degree.nameM.Sc.

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