Tolypocaibols: Antibacterial lipopeptaibols from a Tolypocladium sp. endophyte of the marine macroalga Spongomorpha arcta

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dc.contributor.authorMorehouse, Nicholas J.
dc.contributor.authorFlewelling, Andrew J.
dc.contributor.authorLiu, Dennis Y.
dc.contributor.authorCavanagh, Hannah
dc.contributor.authorLinington, Roger G.
dc.contributor.authorJohnson, John A.
dc.contributor.authorGray, Christopher A.
dc.date.accessioned2024-07-17T17:24:00Z
dc.date.available2024-07-17T17:24:00Z
dc.date.issued2023-06-14
dc.description.abstractTwo new lipopeptaibols, tolypocaibols A (1) and B (2), and the mixed NRPS-polyketide shikimate natural product maximiscin [(P/M)-3)] were isolated from a Tolypocladium sp. fungal endophyte of the marine alga Spongomorpha arcta. Analysis of NMR and mass spectrometry data revealed the amino acid sequences of the lipopeptaibols, which both comprise 11 residues with a valinol C-terminus and a decanoyl acyl chain at the N-terminus. The configuration of the amino acids was determined by Marfey’s analysis. Tolypocaibols A (1) and B (2) showed moderate, selective inhibition against Gram-positive and acid-fast strains, while maximiscin [(P/M)-3)] showed moderate, broad-spectrum inhibition.
dc.description.copyrightThis document is the Accepted Manuscript version of a Published Work that appeared in final form in the Journal of Natural Products, copyright © 2023 American Chemical Society, after peer review and technical editing by the publisher. To access the final edited and published work see: https://pubs.acs.org/articlesonrequest/AOR-I6CDQQTGMZH4VKYARSY5
dc.identifier.issn1520-6025
dc.identifier.urihttps://unbscholar.lib.unb.ca/handle/1882/38041
dc.language.isoen
dc.publisherAmerican Chemical Society
dc.relationNSERC
dc.relationNBIF
dc.relationUNB
dc.relation.hasversionhttps://doi.org/10.1021/acs.jnatprod.3c00233
dc.rightshttp://purl.org/coar/access_right/c_abf2
dc.subject.disciplineChemistry
dc.titleTolypocaibols: Antibacterial lipopeptaibols from a Tolypocladium sp. endophyte of the marine macroalga Spongomorpha arcta
dc.typejournal article
oaire.citation.endPage1535
oaire.citation.issue6
oaire.citation.startPage1529
oaire.citation.titleJournal of Natural Products
oaire.citation.volume86
oaire.license.conditionhttp://creativecommons.org/licenses/by-nc-nd/4.0/
oaire.versionhttp://purl.org/coar/version/c_ab4af688f83e57aa

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