Caryophyllene sesquiterpenes from a Chaetomium globosum endophyte of the Canadian Medicinal plant Empetrum nigrum

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dc.contributor.authorMorehouse, Nicholas J.
dc.contributor.authorClark, Trevor N.
dc.contributor.authorKerr, Russell G.
dc.contributor.authorJohnson, John A.
dc.contributor.authorGray, Christopher A.
dc.date.accessioned2024-07-17T17:25:15Z
dc.date.available2024-07-17T17:25:15Z
dc.date.issued2023-06-02
dc.description.abstractPunctaporonins T (1) and U (2), new caryophyllene sesquiterpenes, were isolated with three known punctaporonins, A (3), B (4), and C (5), from the endophytic fungus Chaetomium globosum (TC2-041). The structures and relative configurations of punctaporonins T and U were elucidated based on a combination of HRESIMS, 1D/2D NMR spectroscopic analysis, and X-ray diffraction analysis whilst their absolute configuration is presumed to be consistent with the co-isolated 3–5 on biogenetic arguments. Compound 1 showed weak inhibitory activity against both Mycobacterium tuberculosis and Staphylococcus aureus.
dc.description.copyrightThis document is the Accepted Manuscript version of a Published Work that appeared in final form in the Journal of Natural Products, copyright © 2023 American Chemical Society, after peer review and technical editing by the publisher. To access the final edited and published work see: https://pubs.acs.org/articlesonrequest/AOR-UYIC7TWSI4YGEMQKR2VP
dc.identifier.issn1520-6025
dc.identifier.urihttps://unbscholar.lib.unb.ca/handle/1882/38042
dc.language.isoen
dc.publisherAmerican Chemical Society
dc.relationNSERC
dc.relationNBIF
dc.relationUNB
dc.relation.hasversionhttps://doi.org/10.1021/acs.jnatprod.2c01159
dc.rightshttp://purl.org/coar/access_right/c_abf2
dc.subject.disciplineChemistry
dc.titleCaryophyllene sesquiterpenes from a Chaetomium globosum endophyte of the Canadian Medicinal plant Empetrum nigrum
dc.typejournal article
oaire.citation.endPage1619
oaire.citation.issue6
oaire.citation.startPage1615
oaire.citation.titleJournal of Natural Products
oaire.citation.volume86
oaire.license.conditionhttp://creativecommons.org/licenses/by-nc-nd/4.0/
oaire.versionhttp://purl.org/coar/version/c_ab4af688f83e57aa

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