Development of electrochemical biosensors for the direct detection of infectious disease

dc.contributor.advisorIgnaszak, Anna
dc.contributor.authorFlynn, Connor Daniel
dc.date.accessioned2023-03-01T16:38:59Z
dc.date.available2023-03-01T16:38:59Z
dc.date.issued2020
dc.date.updated2023-03-01T15:02:55Z
dc.description.abstractInfectious disease detection is an extremely important field, as clinicians and scientists around the world continue to seek improved diagnostics. Electrochemical biosensors represent an emerging class of diagnostic techniques that are rapid, inexpensive, and easily scalable. By combining the intricate interactions of biological molecules with the sensitive techniques of electrochemistry, these biosensors hold great promise in the future of infectious disease sensing. The current thesis explores the development of two such devices, for Lyme disease and hepatitis B, by describing their design, assembly, and effectiveness. The Lyme sensor exploits a known protein-protein interaction between bacterial and human cells to produce a biomimetic sensor capable of binding individual bacteria. This biosensor proves effective at capturing the Lyme bacteria and producing a significant electrochemical response. Likewise, the hepatitis B sensor employs highly specialized surface chemistry to detect hepatitis-specific antigens. Through the development of these sensors, we hope to provide insight into potential devices that can combat these dangerous diseases.
dc.description.copyright© Connor Flynn, 2021
dc.formattext/xml
dc.format.extentxii, 100 pages
dc.format.mediumelectronic
dc.identifier.urihttps://unbscholar.lib.unb.ca/handle/1882/14268
dc.language.isoen_CA
dc.publisherUniversity of New Brunswick
dc.rightshttp://purl.org/coar/access_right/c_abf2
dc.subject.disciplineChemistry
dc.titleDevelopment of electrochemical biosensors for the direct detection of infectious disease
dc.typemaster thesis
thesis.degree.disciplineChemistry
thesis.degree.fullnameMaster of Science
thesis.degree.grantorUniversity of New Brunswick
thesis.degree.levelmasters
thesis.degree.nameM.Sc.

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