Isolation of an antimicrobial racemic phenalenone derivative from a marine-derived Penicillium sp. fungus

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dc.contributor.authorMorehouse, Nicholas J.
dc.contributor.authorGraham, Kelsie M.
dc.contributor.authorCox, Samantha L.
dc.contributor.authorJohnson, John A.
dc.contributor.authorGray, Christopher A.
dc.date.accessioned2024-07-17T17:26:52Z
dc.date.available2024-07-17T17:26:52Z
dc.date.issued2023-10-30
dc.description.abstractA new phenalenone derivative, 2,4,6,9-tetrahydroxy-7-methyl-2-prenyl-1H-phenalene 1,3(2H)-dione (1), was isolated from the ethyl acetate extract of a marine derived Penicillium sp. fungus that exhibited a unique antimicrobial activity profile. The planar structure of 1 was determined through a combination of 1D and 2D NMR experiments, and circular dichroism and polarimetry indicated that it was isolated as a racemic mixture of enantiomers. The antimicrobial activity of 1 was assessed against a panel of Gram-positive and Gram-negative bacteria and fungal strains and it was found to selectively inhibit the growth of Staphylococcus aureus and Mycobacterium tuberculosis. Keywords: Phenalenone, Penicillium, Natural product, Antimicrobial
dc.description.copyrightThis document is the Accepted Manuscript version of a Published Work that appeared in final form in the Canadian Journal of Chemistry, published by Canadian Science Publishing, after peer review and technical editing by the publisher. To access the final edited and published work see https://dx.doi.org/10.1139/cjc-2023-0100
dc.identifier.issn1480-3291
dc.identifier.urihttps://unbscholar.lib.unb.ca/handle/1882/38043
dc.language.isoen
dc.publisherCanadian Science Publishing
dc.relationNatural Sciences and Engineering Research Council of Canada
dc.relationNew Brunswick Innovation Foundation
dc.relation.hasversionhttps://doi.org/10.1139/cjc-2023-0100
dc.rightshttp://purl.org/coar/access_right/c_abf2
dc.subject.disciplineChemistry
dc.titleIsolation of an antimicrobial racemic phenalenone derivative from a marine-derived Penicillium sp. fungus
dc.typejournal article
oaire.citation.endPage90
oaire.citation.issue3
oaire.citation.startPage86
oaire.citation.titleCanadian Journal of Chemistry
oaire.citation.volume102
oaire.license.conditionhttp://creativecommons.org/licenses/by-nc-nd/4.0/
oaire.versionhttp://purl.org/coar/version/c_ab4af688f83e57aa

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